Description

Methyl 2-Chloro-5-Ethynylbenzoate is a high-purity, synthetically valuable organic building block characterized by its reactive ethynyl and ester functional groups. This compound matters for its role as a versatile intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potential drug candidates, particularly for constructing complex heterocycles or conjugated systems via Sonogashira and other cross-coupling reactions.
• Agrochemical Research: Used in developing novel active ingredients for crop protection, where the chloro and ethynyl groups allow for structural diversification and activity optimization.
• Materials Science Precursor: Serves as a monomer or building block for synthesizing specialty polymers, dendrimers, or organic electronic materials with tailored properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags, leveraging the "click chemistry" compatibility of the terminal alkyne for bioconjugation.
• Ligand and Catalyst Development: Acts as a starting material for creating novel ligands or organometallic complexes used in catalytic processes.
• Academic and R&D Laboratories: A valuable reagent for methodological development in organic chemistry and exploring new synthetic pathways.

Basic Information

Product Name	Methyl 2-Chloro-5-Ethynylbenzoate
CAS No.	792912-10-8
Molecular Formula	C10H7ClO2
Molecular Weight	194.61 g/mol
Synonyms	2-Chloro-5-ethynylbenzoic acid methyl ester; Methyl 2-chloro-5-ethynylbenzoate; Benzoic acid, 2-chloro-5-ethynyl-, methyl ester; 5-Ethynyl-2-chlorobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-5-Ethynylbenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. Due to the reactive ethynyl group, prolonged storage under inert atmosphere (e.g., nitrogen or argon) is recommended for optimal long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.