Description

Spiro[3H-Indole-3,3-Pyrrolidin]-2(1H)-One, 2-Ethyl-2-Methyl-, (2R,3S)-Rel- (9Ci) is a high-purity, stereochemically defined spirocyclic indole derivative that serves as a critical advanced intermediate in modern organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. Pharmaceutical R&D teams and fine chemical manufacturers need this precise chiral building block to accelerate the synthesis of potential drug candidates targeting neurological and oncological pathways, where its rigid spiro-fused structure is highly valuable.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.
• Asymmetric Synthesis Building Block: Utilized in stereoselective reactions to introduce complex, polycyclic frameworks into target molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for hit-to-lead optimization in drug discovery.
• Fine Chemical Production: Serves as a precursor for the scaled-up manufacturing of specialized, high-value chemical entities under GMP or ISO-controlled environments.
• Academic & Industrial R&D: Used in methodological development and catalysis research focused on constructing spirocyclic and fused heterocyclic systems.

Basic Information

Item	Details
Product Name	Spiro[3H-Indole-3,3-Pyrrolidin]-2(1H)-One, 2-Ethyl-2-Methyl-, (2R,3S)-Rel- (9Ci)
CAS No.	792903-34-5
Molecular Formula	C14H18N2O
Molecular Weight	230.31 g/mol
Synonyms	rel-(2R,3S)-2-Ethyl-2-methylspiro[3H-indole-3,3'-pyrrolidin]-2'(1'H)-one; (2R,3S)-rel-2-Ethyl-2-methyl-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-2-one; 2-Ethyl-2-methylspiro[indoline-3,3'-pyrrolidin]-2-one (rel-(2R,3S)-); Spiro[indole-3,3'-pyrrolidine] derivative (CAS 792903-34-5); 792903-34-5; (2R,3S)-2-Ethyl-2-methyl-1,2-dihydro-3H-spiro[indole-3,3'-pyrrolidine]-2'-one
EINECS	Contact for details

Quality Control

Our Spiro[3H-Indole-3,3-Pyrrolidin]-2(1H)-One, 2-Ethyl-2-Methyl-, (2R,3S)-Rel- (9Ci) is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess determination and NMR for structural confirmation, to ensure high chemical and isomeric purity suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.