Description

2-Chloro-5-Fluoronicotinonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling critical molecular modifications. Pharmaceutical, agrochemical, and material science R&D teams need this intermediate to construct complex molecules with targeted biological and physical properties.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorinated pyridine core for enhanced bioactivity.
• Material Science Research: Serves as a precursor for creating specialized ligands, functional polymers, and liquid crystal materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	2-Chloro-5-Fluoronicotinonitrile
CAS No.	791644-48-9
Molecular Formula	C6H2ClFN2
Molecular Weight	156.55 g/mol
Synonyms	2-Chloro-5-fluoropyridine-3-carbonitrile; 3-Cyano-2-chloro-5-fluoropyridine; 5-Fluoro-2-chloronicotinonitrile; 2-Chloro-5-fluoro-3-pyridinecarbonitrile; 791644-48-9; 2-Chloro-5-fluoronicotinamide nitrile (precursor); 2-Chloro-5-fluoro-3-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoronicotinonitrile is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) with full traceability are provided for each shipment, supporting development and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.