Description

1-Pyrrolidinecarboxylicacid,2-(Hydroxymethyl)-5-Methyl-,1,1-Dimethylethylester,(2R,5R)-(9Ci) CAS NO 790689-62-2 is a high-purity, stereochemically defined pyrrolidine derivative, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its value lies in its ability to introduce complex, functionalized pyrrolidine motifs, which are privileged scaffolds in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for its potential in creating stereoselective catalysts and bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in areas targeting the central nervous system, infectious diseases, and metabolic disorders.
• Agrochemical Synthesis: Used in the creation of advanced, stereospecific pesticides and herbicides where the specific (2R,5R) configuration can influence biological activity and environmental profile.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in stereoselective chemical transformations to produce enantiomerically pure compounds.
• Peptidomimetics Research: The pyrrolidine core is a common proline mimic; this ester derivative is utilized in constructing novel peptidomimetic structures for biochemical and therapeutic studies.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for producing high-value, complex organic molecules for various industrial applications.
• Academic & R&D: A valuable reagent for universities and research institutions exploring new synthetic methodologies and the structure-activity relationships of nitrogen-containing heterocycles.

Basic Information

Product Name	1-Pyrrolidinecarboxylicacid,2-(Hydroxymethyl)-5-Methyl-,1,1-Dimethylethylester,(2R,5R)-(9Ci)
CAS No.	790689-62-2
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	(2R,5R)-2-(Hydroxymethyl)-5-methylpyrrolidine-1-carboxylic acid tert-butyl ester; tert-Butyl (2R,5R)-2-(hydroxymethyl)-5-methylpyrrolidine-1-carboxylate; (2R,5R)-1-Boc-2-hydroxymethyl-5-methylpyrrolidine; (2R,5R)-2-Hydroxymethyl-5-methyl-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; (2R,5R)-N-Boc-2-(hydroxymethyl)-5-methylpyrrolidine; (2R,5R)-1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)-5-methylpyrrolidine; (2R,5R)-2-Methyl-5-(hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, stereochemical purity, and potency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and commercial projects requiring compliance with cGMP and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture and prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (2R,5R)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.