Description

1-Piperidinecarboxylicacid,4-Hydroxy-2-Methyl-,1,1-Dimethylethylester,(2S,4R)-(9Ci) is a high-purity, stereochemically defined piperidine derivative that serves as a critical chiral building block in advanced organic synthesis. Its precise stereochemistry and functional groups make it an invaluable intermediate for constructing complex molecular architectures with high enantiomeric purity. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and fine chemicals, where structural precision is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Employed as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereocenters with high selectivity.
• Peptidomimetics & Bioactive Molecule Construction: Used to incorporate constrained piperidine scaffolds into peptide analogs and other bioactive compounds to modulate pharmacokinetic properties.
• Agrochemical Research: Serves as a building block for developing novel, enantiomerically pure crop protection agents and pesticides.
• Academic & Process Chemistry: A valuable reagent for methodological studies in organic chemistry and for scaling up synthetic routes in process chemistry.
• Ligand & Catalyst Development: Potential precursor for the synthesis of novel chiral ligands and organocatalysts used in enantioselective transformations.

Basic Information

Item	Detail
Product Name	1-Piperidinecarboxylicacid,4-Hydroxy-2-Methyl-,1,1-Dimethylethylester,(2S,4R)-(9Ci)
CAS No.	790667-91-3
Molecular Formula	C12H23NO3
Molecular Weight	229.32 g/mol
Synonyms	(2S,4R)-4-Hydroxy-2-methylpiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl (2S,4R)-4-hydroxy-2-methylpiperidine-1-carboxylate; (2S,4R)-1-Boc-4-hydroxy-2-methylpiperidine; (2S,4R)-4-Hydroxy-2-methyl-1-N-Boc-piperidine; (2S,4R)-N-Boc-4-hydroxy-2-methylpiperidine; (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxy-2-methylpiperidine; 1-Piperidinecarboxylic acid, 4-hydroxy-2-methyl-, 1,1-dimethylethyl ester, (2S,4R)-
EINECS	Contact for details

Quality Control

Our production of 1-Piperidinecarboxylicacid,4-Hydroxy-2-Methyl-,1,1-Dimethylethylester,(2S,4R)-(9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for pharmaceutical R&D. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment. Our quality system is designed to support development under cGMP guidelines when required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.