Description

(2S)-2-Methyl-4-Oxo-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral piperidinone derivative, serving as a critical building block in modern organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex pharmaceutical intermediates, particularly for active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and fine chemical industries who require reliable access to high-quality chiral synthons.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective reactions to introduce the (2S)-2-methyl-4-oxo-piperidine moiety.
• API Development: Serves as a building block for the construction of more complex molecular architectures found in final active pharmaceutical ingredients.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for commercial manufacturing.
• Agrochemical Synthesis: Potential intermediate in the creation of advanced, chiral agrochemicals requiring specific stereochemistry for efficacy.

Basic Information

Product Name	(2S)-2-Methyl-4-Oxo-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	790667-49-1
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	tert-Butyl (2S)-2-methyl-4-oxopiperidine-1-carboxylate; (S)-1-Boc-2-methyl-4-piperidone; 1-Boc-(2S)-2-methyl-4-piperidone; (S)-2-Methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-2(S)-methyl-4-piperidone; (2S)-1-(tert-Butoxycarbonyl)-2-methyl-4-piperidinone; 790667-49-1; Boc-2(S)-Me-4-piperidone
EINECS	Contact for details

Quality Control

Our (2S)-2-Methyl-4-Oxo-Piperidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.