Description

Flumazenil is a highly selective benzodiazepine receptor antagonist, primarily used to reverse the sedative effects of benzodiazepines. Its precise mechanism of action makes it a critical agent in clinical and research settings for managing benzodiazepine overdose and anesthesia reversal. This compound is essential for pharmaceutical manufacturers, research institutions, and clinical laboratories engaged in neuroscience, anesthesiology, and toxicology studies.

Application

• Benzodiazepine Overdose Reversal: The primary clinical application as an emergency antidote to reverse sedation, respiratory depression, and coma induced by benzodiazepines.
• Anesthesia & Sedation Management: Used post-operatively to accelerate recovery from benzodiazepine-induced sedation and general anesthesia.
• Pharmaceutical Active Ingredient: Serves as the key active pharmaceutical ingredient (API) in the formulation of injectable reversal agents.
• Neuroscience Research: A vital tool in preclinical and clinical research for studying the GABAA receptor complex, neurotransmitter systems, and mechanisms of sedation.
• Diagnostic Aid: Employed in specialized diagnostic procedures to differentiate between psychiatric and neurological conditions.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for drug testing and method validation.

Basic Information

Product Name	Flumazenil
CAS No.	787558-81-4
Molecular Formula	C15H14FN3O3
Molecular Weight	303.29 g/mol
Synonyms	Ro 15-1788; Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate; Anexate; Lanexat; Flumazepil; Benzodiazepine Antagonist Ro 15-1788; 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
EINECS	Contact for details

Quality Control

Our Flumazenil is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to ensure it meets high-purity standards suitable for pharmaceutical and research use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.