Description

Dexrazoxane Hydrochloride is a cardioprotective agent and a potent intracellular iron chelator. It is primarily used to mitigate the cardiotoxic side effects associated with certain chemotherapeutic drugs, particularly anthracyclines like doxorubicin. This compound is of critical importance to the pharmaceutical industry for the formulation of protective adjunct therapies in oncology. Its high-purity grade makes it suitable for research and development as well as commercial drug manufacturing.

Application

• Oncological Adjunct Therapy: Primary use as a cardioprotectant to reduce the incidence and severity of cardiomyopathy induced by anthracycline chemotherapy.
• Pharmaceutical Intermediates: Serves as a key active pharmaceutical ingredient (API) in the production of finished dosage forms, such as injectable solutions or lyophilized powders.
• Biomedical Research: Utilized in preclinical and clinical studies to investigate mechanisms of chemoprotection and iron chelation in cellular models.
• Drug Formulation Development: Employed in the R&D of new combination therapies and delivery systems aimed at enhancing patient safety during cancer treatment.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation in pharmacopeial testing.

Basic Information

Product Name	Dexrazoxane Hydrochloride
CAS No.	149003-01-0
Molecular Formula	C11H16N4O4 • HCl
Molecular Weight	288.73 g/mol (Free base: 268.27)
Synonyms	Dexrazoxane HCl; (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione hydrochloride; ICRF-187 hydrochloride; ADR-529 hydrochloride; Cardioxane; Zinecard; Razoxane metabolite; (+)-1,2-Bis(3,5-dioxopiperazinyl)propane hydrochloride
EINECS	Contact for details

Quality Control

Our Dexrazoxane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide full traceability and support with regulatory documentation. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	[α]20/D: +15.0° to +19.0° (c=1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.