Description

Icrf 193 is a potent and specific inhibitor of DNA topoisomerase II, functioning as a bisdioxopiperazine derivative. This compound is crucial for biochemical and pharmacological research, particularly in studies of cell cycle regulation, DNA replication, and the mechanisms of chemotherapeutic agents. It serves as an essential research tool for scientists in oncology, molecular biology, and drug discovery programs investigating topoisomerase function and anticancer strategies.

Application

• Primary research tool for studying DNA topoisomerase II (Topo II) enzyme function and inhibition mechanisms.
• Used in oncology research to investigate cell cycle arrest, apoptosis, and the effects on cancer cell lines.
• Critical reagent in biochemical assays to understand the role of Topo II in DNA replication, transcription, and chromosome segregation.
• Employed in pharmacological studies to explore chemotherapeutic adjuvants and drug resistance mechanisms.
• Utilized in molecular biology research for probing protein-DNA interactions and genomic stability.
• Reference standard in analytical method development and quality control for related pharmaceutical compounds.

Basic Information

Product Name	Icrf 193
CAS No.	21416-68-2
Molecular Formula	C20H22N4O4
Molecular Weight	382.41 g/mol
Synonyms	ICRF-193; ICRF193; (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; NSC 169780; Dexrazoxane derivative; Topoisomerase II catalytic inhibitor; Bisdioxopiperazine ICRF-193; 1,2-Bis(3,5-dioxopiperazinyl)propane
EINECS	Contact for details

Quality Control

Our Icrf 193 is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be provided to meet the rigorous demands of academic and pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.