Description

Calcium Folinate is the calcium salt of folinic acid (5-formyl tetrahydrofolic acid), a vital biochemical intermediate in cellular metabolism. It serves as a critical antidote and rescue agent in high-dose methotrexate chemotherapy, protecting healthy cells while enhancing the efficacy of certain fluoropyrimidine-based treatments. This essential pharmaceutical ingredient is primarily required by manufacturers in the oncology, nutraceutical, and advanced pharmaceutical formulation sectors, where consistent purity and reliable supply are paramount.

Application

• Oncology Therapeutics: As a rescue agent (leucovorin rescue) following high-dose methotrexate therapy to reduce systemic toxicity.
• Chemotherapy Modulator: Used in combination with fluorouracil (5-FU) for enhanced cytotoxicity in the treatment of colorectal and other cancers.
• Antidote Formulations: For the counteraction of folic acid antagonists and dihydrofolate reductase inhibitors.
• Megaloblastic Anemia Treatment: As an active form of folate in cases where folic acid conversion is impaired.
• Pharmaceutical Intermediates: Serves as a key starting material or active ingredient in sterile injectable and oral dosage forms.
• Biochemical Research: Used in cell culture media and as a reagent in studies of folate metabolism and one-carbon transfer reactions.

Basic Information

Product Name	Calcium Folinate
CAS No.	1492-18-8
Molecular Formula	C20H21CaN7O7
Molecular Weight	511.50 g/mol
Synonyms	Leucovorin Calcium; Folinic Acid Calcium Salt; 5-Formyltetrahydrofolate Calcium; Citrovorum Factor; Calcium Leucovorin; (6S)-5,6,7,8-Tetrahydrofolate; Antifolate Rescue Agent; 5-CHO-THF Calcium
EINECS	Contact for details

Quality Control

Our Calcium Folinate is manufactured under strict quality systems, with specifications designed to meet or exceed relevant pharmacopoeial standards such as USP and EP. Every batch undergoes comprehensive analytical testing, including assay, impurity profiling, and microbiological examination. A Certificate of Analysis (COA) documenting all critical quality attributes is provided with each shipment to ensure full traceability and regulatory compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a low-humidity environment to prevent degradation and clumping. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to slightly yellow powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (Anhydrous Basis)	97.0% - 102.0%
pH (1% Solution)	6.5 - 8.5
Water Content (KF)	≤ 8.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with EP/USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.