Description

Imidazo[1,2-A]Pyridine, 2,3-Dihydro-2-Phenyl-6-(Trifluoromethyl)-, (2R)- is a high-value, chiral organic intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters because its unique imidazopyridine core, combined with a stereogenic center and a trifluoromethyl group, makes it a critical building block for developing novel bioactive molecules. Pharmaceutical R&D and fine chemical manufacturers need this precise chiral synthon to create potential drug candidates targeting a range of therapeutic areas, where the (2R)- enantiomer provides specific and optimized biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drugs.
• Agrochemical Synthesis: Used in the discovery and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Employed in organometallic chemistry for creating novel chiral ligands and catalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a precursor for organic electronic materials and photoactive compounds due to the conjugated imidazopyridine system.
• Medicinal Chemistry Library Building: A valuable component for constructing diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	Imidazo[1,2-A]Pyridine, 2,3-Dihydro-2-Phenyl-6-(Trifluoromethyl)-, (2R)-
CAS No.	785784-11-4
Molecular Formula	C14H11F3N2
Molecular Weight	264.25 g/mol
Synonyms	(2R)-2,3-Dihydro-2-phenyl-6-(trifluoromethyl)imidazo[1,2-a]pyridine; (R)-2,3-Dihydro-2-phenyl-6-(trifluoromethyl)imidazo[1,2-a]pyridine; (R)-2-Phenyl-6-(trifluoromethyl)-2,3-dihydroimidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 2,3-dihydro-2-phenyl-6-(trifluoromethyl)-, (2R)-; 785784-11-4; (R)-enantiomer of 2-phenyl-6-(trifluoromethyl)-2,3-dihydroimidazo[1,2-a]pyridine
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to meet exacting customer specifications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkalis and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.