Description

2-Chloro-5-Iodo-4-(Trifluoromethyl)Pyrimidine is a high-value, multi-functional halogenated pyrimidine building block essential for advanced organic synthesis. Its unique structure, featuring chlorine, iodine, and trifluoromethyl substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Development: Used to create novel herbicides, fungicides, and insecticides by introducing the halogenated pyrimidine core into active molecules.
• Material Science Research: Serves as a building block for organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The iodine and chlorine atoms provide orthogonal reactivity for sequential palladium-catalyzed cross-coupling (e.g., Suzuki, Sonogashira) to create diverse compound libraries.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a scaffold for developing molecular probes and tags for studying biological systems.

Basic Information

Product Name	2-Chloro-5-Iodo-4-(Trifluoromethyl)Pyrimidine
CAS No.	785777-99-3
Molecular Formula	C5HClF3IN2
Molecular Weight	307.92 g/mol
Synonyms	2-Chloro-5-iodo-4-(trifluoromethyl)pyrimidine; 4-(Trifluoromethyl)-2-chloro-5-iodopyrimidine; 5-Iodo-2-chloro-4-trifluoromethylpyrimidine; 2-Chloro-5-iodo-4-trifluoromethylpyrimidine; Pyrimidine, 2-chloro-5-iodo-4-(trifluoromethyl)-; 785777-99-3
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodo-4-(Trifluoromethyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR (1H, 13C, 19F) for structural confirmation, and GC-MS for solvent residue analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.