Description

(1S)-2,2,2-Trifluoro-1-(2-Pyridyl)Ethylamine is a high-purity chiral amine building block featuring a trifluoromethyl group and a pyridine moiety, offering unique electronic and steric properties for advanced synthesis. This compound is critical for pharmaceutical research and development, particularly in the creation of novel active pharmaceutical ingredients (APIs) where its structural motifs can enhance metabolic stability and binding affinity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of potential drug candidates, especially for central nervous system (CNS) and antiviral targets.
• Ligand Precursor: Serves as a starting material for the synthesis of novel chiral ligands used in asymmetric catalysis (e.g., for hydrogenation or cross-coupling reactions).
• Agrochemical Research: Used in the development of advanced crop protection agents, leveraging the biological activity often associated with the trifluoromethylpyridine structure.
• Fluorinated Building Block: Essential for introducing the trifluoromethyl group into complex molecules to modulate lipophilicity, metabolic stability, and bioavailability.
• Chemical Biology Probe Development: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	(1S)-2,2,2-Trifluoro-1-(2-Pyridyl)Ethylamine
CAS No.	783294-93-9
Molecular Formula	C7H7F3N2
Molecular Weight	176.14 g/mol
Synonyms	(S)-2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amine; (S)-1-(2-Pyridyl)-2,2,2-trifluoroethylamine; (S)-α-(Trifluoromethyl)-2-pyridineethanamine; (1S)-1-(2-Pyridinyl)-2,2,2-trifluoroethanamine; (S)-2,2,2-Trifluoro-1-(2-pyridinyl)ethylamine; (S)-TFPEA; (S)-Trifluoro(2-pyridyl)ethylamine
EINECS	Contact for details

Quality Control

Our (1S)-2,2,2-Trifluoro-1-(2-Pyridyl)Ethylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.