Description

2,4(1H,3H)-Pyrimidinedione, 5-[(2S,5S)-5-(Hydroxymethyl)-2-Pyrrolidinyl]- (9Ci) is a high-purity, chiral pyrimidine derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block for the development of novel pharmaceuticals and bioactive molecules, particularly those targeting nucleoside analogs and enzyme inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of antiviral, anticancer, and other therapeutic nucleoside analogs.
• Medicinal Chemistry Research: Used as a precision building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Biochemical Research: Potential substrate or inhibitor for enzymatic studies involving nucleoside-processing enzymes.
• Process Chemistry: Serves as a critical intermediate in the scalable synthesis of more complex active pharmaceutical ingredients (APIs).
• Academic Research: Valuable for synthetic organic chemists exploring novel heterocyclic chemistry and stereoselective transformations.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione, 5-[(2S,5S)-5-(Hydroxymethyl)-2-Pyrrolidinyl]- (9Ci)
CAS No.	783290-11-9
Molecular Formula	C9H13N3O3
Molecular Weight	211.22 g/mol
Synonyms	5-[(2S,5S)-5-(Hydroxymethyl)-2-pyrrolidinyl]pyrimidine-2,4(1H,3H)-dione; (2S,5S)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-(hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester (related protected form); Chiral Dihydroxypyrrolidinyl Uracil Derivative; (2S,5S)-5-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-2-(hydroxymethyl)pyrrolidine; 5-((2S,5S)-5-(Hydroxymethyl)pyrrolidin-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of 2,4(1H,3H)-Pyrimidinedione, 5-[(2S,5S)-5-(Hydroxymethyl)-2-Pyrrolidinyl]- (9Ci) is characterized and released based on comprehensive analytical data, including chiral purity verification. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.