Description

Bromo-Peg3-T-Butyl Ester is a specialized bifunctional PEG linker featuring a reactive bromo group and a protected carboxylic acid terminus. This compound is a critical building block in the synthesis of complex molecules, enabling precise conjugation and controlled release strategies. It is primarily utilized by researchers and manufacturers in the pharmaceutical and bioconjugation sectors for developing antibody-drug conjugates (ADCs), prodrugs, and advanced polymer materials.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key intermediate for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies.
• Prodrug Synthesis: Used to create prodrugs where the active pharmaceutical ingredient (API) is released upon specific biological triggers.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for synthesizing and modifying PEG-based polymers and hydrogels.
• Bioconjugation: Facilitates the site-specific attachment of drugs, dyes, or other molecules to peptides, proteins, or surfaces.
• Chemical Biology Probes: Employed in the development of tools for studying biological processes and target engagement.
• Material Science: Used in the creation of functionalized surfaces and smart materials with tailored properties.

Basic Information

Product Name	Bromo-Peg3-T-Butyl Ester
CAS No.	782475-37-0
Molecular Formula	C13H25BrO5
Molecular Weight	341.24 g/mol
Synonyms	2,5,8,11-Tetraoxatridecan-13-oic acid, 13-bromo-3,6,9-trioxa-12-azatetradecan-1-oic acid tert-butyl ester (related structure); 1-Bromo-3,6,9-trioxaundecan-11-oic acid tert-butyl ester; Bromo-PEG3-t-butyl ester; tert-Butyl 3,6,9-trioxa-12-azatetradecan-14-oate (common misassignment); Bromo-triethylene glycol t-butyl ester; PEG3-Br-tBu ester; Br-PEG3-COOtBu
EINECS	Contact for details

Quality Control

Our Bromo-Peg3-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content, to ensure it meets the high standards required for research and pharmaceutical development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.