Description

2-(Bromomethyl)-6-(Trifluoromethyl)Pyridine is a versatile and highly functionalized pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive bromomethyl group and a stable trifluoromethyl moiety, makes it an invaluable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a trifluoromethylpyridine scaffold to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and organocatalysis.
• Material Science Precursor: Employed in the synthesis of organic electronic materials, such as charge-transport layers or emissive materials for OLEDs.
• Chemical Biology Probe Synthesis: Useful for incorporating fluorinated tags and reactive handles into molecules for imaging, labeling, and proteomics studies.
• Cross-Coupling Reactions: The bromomethyl group acts as an excellent electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) for carbon-carbon bond formation.

Basic Information

Product Name	2-(Bromomethyl)-6-(Trifluoromethyl)Pyridine
CAS No.	781637-62-5
Molecular Formula	C7H5BrF3N
Molecular Weight	240.02 g/mol
Synonyms	6-(Trifluoromethyl)-2-pyridinemethanol, bromo derivative; 2-(Bromomethyl)-6-(trifluoromethyl)pyridine; 2-Pyridinemethanol, 6-(trifluoromethyl)-, bromo derivative; (6-(Trifluoromethyl)pyridin-2-yl)methyl bromide; 2-Bromomethyl-6-trifluoromethylpyridine; α-Bromo-6-(trifluoromethyl)-2-picoline
EINECS	Contact for details

Quality Control

Every batch of 2-(Bromomethyl)-6-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.