Description

tert-Butyl (3R)-3-Hydroxy-3,6-dihydropyridine-1(2H)-carboxylate is a high-purity, chiral building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate for constructing complex molecular architectures, particularly in the pharmaceutical sector where stereochemical control is paramount. It is primarily needed by R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially in the areas of neurological and cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized in the construction of stereochemically defined piperidine and related heterocyclic scaffolds.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Used in scaling up synthetic routes for preclinical and clinical trial material production.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services.
• Academic Research: Employed in university and institutional labs for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	tert-Butyl (3R)-3-Hydroxy-3,6-dihydropyridine-1(2H)-carboxylate
CAS No.	780782-29-8
Molecular Formula	C10H17NO3
Molecular Weight	199.25 g/mol
Synonyms	1-Boc-3R-hydroxy-1,2,3,6-tetrahydropyridine; (R)-1-Boc-3-hydroxypiperidine-4-ene; (3R)-1-(tert-Butoxycarbonyl)-3-hydroxy-3,6-dihydro-2H-pyridine; (R)-tert-Butyl 3-hydroxy-3,6-dihydro-2H-pyridine-1-carboxylate; (R)-N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine; (R)-3-Hydroxy-N-Boc-3,6-dihydropyridine; 780782-29-8; Boc-3R-OH-1,2,3,6-THP
EINECS	Contact for details

Quality Control

Our tert-Butyl (3R)-3-Hydroxy-3,6-dihydropyridine-1(2H)-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by spectroscopic methods. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.