Description

tert-Butyl (3S)-3-Hydroxy-3,6-dihydropyridine-1(2H)-carboxylate is a high-value, chiral building block and protected intermediate essential for advanced organic synthesis. Its core value lies in providing a stereochemically defined scaffold for constructing complex nitrogen-containing heterocycles, a critical step in modern pharmaceutical development. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-infective therapies.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to introduce the (3S)-3-hydroxy-1,2,3,6-tetrahydropyridine moiety into target molecules.
• Medicinal Chemistry: Serves as a versatile precursor for generating compound libraries in structure-activity relationship (SAR) studies.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, or insecticides that require complex heterocyclic structures.
• Academic Research: A valuable reagent for methodological development in organic chemistry and catalysis studies.

Basic Information

Product Name	tert-Butyl (3S)-3-Hydroxy-3,6-dihydropyridine-1(2H)-carboxylate
CAS No.	780782-28-7
Molecular Formula	C10H17NO3
Molecular Weight	199.25 g/mol
Synonyms	1-Boc-3(S)-hydroxy-1,2,3,6-tetrahydropyridine; (3S)-1-(tert-Butoxycarbonyl)-3-hydroxy-3,6-dihydro-2H-pyridine; (S)-1-Boc-3-hydroxypiperidine enamine; tert-Butyl (3S)-3-hydroxy-1,2,3,6-tetrahydropyridine-1-carboxylate; (S)-3-Hydroxy-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butyl ester; 1-N-Boc-(3S)-3-hydroxy-1,2,3,6-tetrahydropyridine; BOC-3(S)-OH-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl (3S)-3-Hydroxy-3,6-dihydropyridine-1(2H)-carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.