Description

2-(5-Chloropyridin-2-Yl)-2,2-Difluoroethanamine is a high-value, multi-functional organic intermediate featuring a pyridine core with chloro and difluoroethylamine substituents. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced agrochemicals, where its unique halogenated structure enables precise molecular modifications. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, insecticides, and fungicides, leveraging the bioactivity of the chloropyridine moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic electronic materials and functional polymers.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trials.

Basic Information

Product Name	2-(5-Chloropyridin-2-Yl)-2,2-Difluoroethanamine
CAS No.	780769-87-1
Molecular Formula	C7H7ClF2N2
Molecular Weight	192.59 g/mol
Synonyms	2-(5-Chloro-2-pyridinyl)-2,2-difluoroethanamine; 2,2-Difluoro-2-(5-chloropyridin-2-yl)ethanamine; 5-Chloro-2-(2,2-difluoroethylamino)pyridine; 2-Amino-1,1-difluoro-1-(5-chloropyridin-2-yl)ethane; 780769-87-1; 2-(5-Chloropyridin-2-yl)-2,2-difluoroethylamine
EINECS	Contact for details

Quality Control

Every batch of 2-(5-Chloropyridin-2-Yl)-2,2-Difluoroethanamine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, GC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.