Description

5-Fluoro-2-Nitropyridine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its unique reactivity profile, where the electron-withdrawing nitro group and fluorine atom at specific positions on the pyridine ring enable precise chemical modifications. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated nitropyridine core.
• Material Science Precursor: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The fluorine atom is readily displaced by various nucleophiles, allowing for the introduction of diverse functional groups.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for methodological studies and the synthesis of novel chemical libraries.

Basic Information

Product Name	5-Fluoro-2-Nitropyridine
CAS No.	779345-37-8
Molecular Formula	C5H3FN2O2
Molecular Weight	142.09 g/mol
Synonyms	2-Nitro-5-fluoropyridine; 5-Fluoro-2-nitropyridine; 5-Fluoropyridine-2-nitropyridine; 2-Nitro-5-fluoropyridine; Fluoronitropyridine; 779345-37-8; 5-F-2-NO2-Pyridine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures batch-to-batch consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.