Description

Cyclopropanecarboxylic Acid, 2-(1E)-1-Propenyl-, Methyl Ester, (1R,2S)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its unique cyclopropane ring fused with a propenyl ester functionality makes it a valuable precursor for constructing complex molecular architectures with precise three-dimensional control. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where its defined stereochemistry is critical for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, antiviral, or anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the cyclopropane moiety can impart specific biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in asymmetric synthesis.
• Fragrance and Flavor Chemistry: Potential use as an intermediate for creating unique, complex odorants and flavor molecules due to its strained ring structure.
• Material Science Research: Investigated as a monomer or cross-linking agent for developing polymers with specialized thermal or mechanical properties.
• Academic and Contract Research: Essential for methodological studies in organic chemistry, particularly in reactions involving cyclopropanes and stereoselective transformations.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-(1E)-1-Propenyl-, Methyl Ester, (1R,2S)- (9Ci)
CAS No.	777918-01-1
Molecular Formula	C8H12O2
Molecular Weight	140.18 g/mol
Synonyms	(1R,2S)-Methyl 2-[(1E)-1-propen-1-yl]cyclopropanecarboxylate; Methyl (1R,2S)-2-[(1E)-1-Propen-1-yl]cyclopropanecarboxylate; (1R,2S)-rel-2-[(1E)-1-Propen-1-yl]cyclopropanecarboxylic Acid Methyl Ester; Chiral Methyl Cyclopropanecarboxylate Derivative; (1R,2S)-2-(1-Propenyl)cyclopropanecarboxylic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our production of Cyclopropanecarboxylic Acid, 2-(1E)-1-Propenyl-, Methyl Ester, (1R,2S)- (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for its application in sensitive syntheses. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing chiral purity, chemical purity, and identity confirmation. We employ advanced analytical techniques including Chiral HPLC, GC, and NMR to verify specifications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (1R,2S)
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.