Description

D-Proline, 5-Methyl-, Methyl Ester, cis- (9Ci) is a high-purity, non-natural amino acid derivative characterized by its specific stereochemistry at the proline ring and the methyl ester functional group. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the construction of complex molecules with precise three-dimensional control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptidomimetic drug discovery programs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce constrained proline analogs, influencing peptide secondary structure and biological activity.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands or organocatalysts used in enantioselective transformations.
• Chemical Biology Research: Employed as a molecular probe to study enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Agrochemical Synthesis: Potential intermediate in the development of chiral herbicides, fungicides, or plant growth regulators.
• Academic & R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research laboratories.

Basic Information

Product Name	D-Proline, 5-Methyl-, Methyl Ester, cis- (9Ci)
CAS No.	775223-82-0
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	Methyl (2R,5S)-5-methylpyrrolidine-2-carboxylate; cis-5-Methyl-D-proline methyl ester; (2R,5S)-5-Methylpyrrolidine-2-carboxylic acid methyl ester; D-cis-5-Methylproline methyl ester; Methyl D-cis-5-methylprolinate; (2R,5S)-Methyl 5-methylpyrrolidine-2-carboxylate; 775223-82-0; (R-cis)-5-Methylproline methyl ester
EINECS	Contact for details

Quality Control

Our D-Proline, 5-Methyl-, Methyl Ester, cis- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and enantiomeric excess is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Enantiomeric Excess)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.