Description

3-Pyridinecarboxamide, 4-[[2-(5-Chloro-2-Fluorophenyl)-6,7-Dihydro-5H-Cyclopentapyrimidin-4-Yl]Amino]-n-Methyl- (9Ci) is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 773138-82-2. This compound is valued for its role as a key building block in the synthesis of novel, targeted therapeutic agents, offering researchers and manufacturers a critical component for drug discovery and development. It is primarily sought by pharmaceutical R&D laboratories and fine chemical producers engaged in creating next-generation small molecule drugs, particularly in oncology and other specialized therapeutic areas.

Application

This specialized intermediate serves critical functions in advanced chemical synthesis. Its primary applications include:

• Pharmaceutical Intermediate: Serving as a core scaffold or precursor in the synthesis of novel active pharmaceutical ingredients (APIs) for targeted therapies.
• Kinase Inhibitor Research: Used in the research and development of potent and selective kinase inhibitors, a major class of drugs for cancer and inflammatory diseases.
• Medicinal Chemistry: Enabling structure-activity relationship (SAR) studies and lead optimization campaigns in drug discovery pipelines.
• Preclinical Development: Supplying material for the synthesis of compounds required for pharmacological testing, toxicology studies, and formulation development.
• Custom Synthesis: Acting as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Chemical Biology Probes: Utilized in the creation of chemical probes to study specific biological pathways and protein functions.

Basic Information

Product Name	3-Pyridinecarboxamide, 4-[[2-(5-Chloro-2-Fluorophenyl)-6,7-Dihydro-5H-Cyclopentapyrimidin-4-Yl]Amino]-n-Methyl- (9Ci)
CAS No.	773138-82-2
Molecular Formula	C20H17ClFN5O
Molecular Weight	397.84 g/mol
Synonyms	4-[[2-(5-Chloro-2-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]amino]-N-methyl-3-pyridinecarboxamide; UNII-9F8K7F5F8T; 9F8K7F5F8T; BDBM50191085; AKOS025310806; ZINC000103014535; A1B.001.003.002.001.001.001; 773138-82-2
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring full traceability and compliance with your research or cGMP guidelines as required. Specifications are designed to meet the exacting standards of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The material may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider using inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.