Description

Ethyl 5-Bromo-2-(Trifluoromethoxy)Benzoate is a high-purity, advanced pharmaceutical intermediate characterized by its bromo and trifluoromethoxy functional groups. This compound is critical for medicinal chemists in the research and development of novel active pharmaceutical ingredients (APIs), particularly in the synthesis of complex molecules for therapeutic applications. It is primarily utilized by R&D laboratories and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated and fluorinated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or precursor for synthesizing specialty polymers and liquid crystals with unique electronic or optical properties.
• Chemical Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and other metal-catalyzed transformations to construct complex biaryl structures.
• Fluorine Chemistry Studies: An important compound for research into the effects of fluorine substitution on molecular conformation, lipophilicity, and metabolic stability.

Basic Information

Product Name	Ethyl 5-Bromo-2-(Trifluoromethoxy)Benzoate
CAS No.	773135-66-3
Molecular Formula	C10H8BrF3O3
Molecular Weight	313.07 g/mol
Synonyms	5-Bromo-2-(trifluoromethoxy)benzoic acid ethyl ester; Ethyl 5-bromo-2-(trifluoromethoxy)benzoate; Benzoic acid, 5-bromo-2-(trifluoromethoxy)-, ethyl ester; 2-(Trifluoromethoxy)-5-bromobenzoic acid ethyl ester; Ethyl 5-bromo-α,α,α-trifluoro-o-anisate
EINECS	Contact for details

Quality Control

Our Ethyl 5-Bromo-2-(Trifluoromethoxy)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.