Description

4-(2,2-Dimethyl-Propionylamino)-Nicotinic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is essential for research and development chemists, process development scientists, and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and novel APIs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for pharmaceutical manufacturing.
• Fine Chemical Synthesis: Serves as a specialized building block for creating complex organic molecules with specific functional groups.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	4-(2,2-Dimethyl-Propionylamino)-Nicotinic Acid Methyl Ester
CAS No.	773134-09-1
Molecular Formula	C13H18N2O3
Molecular Weight	250.30 g/mol
Synonyms	Methyl 4-(2,2-dimethylpropanamido)nicotinate; 4-(Pivalamido)nicotinic Acid Methyl Ester; 4-(2,2-Dimethylpropionylamino)nicotinic Acid Methyl Ester; 4-(Pivaloylamino)nicotinic Acid Methyl Ester; Nicotinic acid, 4-[(2,2-dimethyl-1-oxopropyl)amino]-, methyl ester; Methyl 4-(pivalamido)nicotinate; 773134-09-1; Pivalic acid 4-(methoxycarbonyl)-3-pyridylamide
EINECS	Contact for details

Quality Control

Our 4-(2,2-Dimethyl-Propionylamino)-Nicotinic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.