Description

5'-Fluorospiro[Cyclopropane-1,3'-Indolin]-2'-One is a high-value, fluorinated spirocyclic oxindole derivative, serving as a critical synthetic intermediate in modern organic and medicinal chemistry. Its unique spirocyclic architecture, incorporating a cyclopropane ring and a fluorinated indolinone core, makes it an essential building block for constructing complex molecular scaffolds with potential biological activity. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and for structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key precursor in the research and development of new drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging the bioactivity of the spirocyclic oxindole structure.
• Chemical Biology Probe: Serves as a scaffold for creating molecular probes to study enzyme function and biological pathways.
• Advanced Material Research: Investigated as a building block for functional organic materials due to its rigid, three-dimensional structure.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development in synthetic organic chemistry.

Basic Information

Product Name	5'-Fluorospiro[Cyclopropane-1,3'-Indolin]-2'-One
CAS No.	769965-95-9
Molecular Formula	C10H8FNO
Molecular Weight	177.18 g/mol
Synonyms	5'-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one; 2H-Indol-2-one, 1,3-dihydro-5'-fluoro-1,1'-spiro[cyclopropane-1,3'-]-; 5-Fluoro-1,1'-spiro[cyclopropane-1,3'-indolin]-2'-one; 5-Fluorospiro[cyclopropane-1,3'-indolin]-2'-one; Spiro[cyclopropane-1,3'-indoline]-2'-one, 5'-fluoro-; 769965-95-9; 5'-Fluoro-spiro[cyclopropane-1,3'-indolin]-2'-one
EINECS	Contact for details

Quality Control

Our 5'-Fluorospiro[Cyclopropane-1,3'-Indolin]-2'-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound should be kept under an inert atmosphere for long-term storage to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.