Description

(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid is a high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its complex stereochemistry and functional groups, which make it a critical building block for novel therapeutic agents. It is primarily sought after by R&D laboratories and pharmaceutical manufacturers engaged in the synthesis of complex small-molecule drugs, particularly those targeting metabolic and inflammatory pathways.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Reference Standard: Employed as an analytical standard for method development, validation, and quality control in API manufacturing.
• Process Chemistry: Integral in scaling up synthetic routes from laboratory to pilot plant and commercial production scales.
• Biochemical Research: Potential tool compound for studying specific enzymatic interactions and biological pathways in vitro.

Basic Information

Product Name	(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid
CAS No.	769908-13-6
Molecular Formula	C29H28FNO4
Molecular Weight	473.54 g/mol
Synonyms	7-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid; Pitavastatin intermediate; NK-104 intermediate; (3R,5R,6E)-Pitavastatin side chain acid; Livalo® synthetic precursor; (E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxyhept-6-enoic acid
EINECS	Contact for details

Quality Control

Our (3R,5R,6E)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinyl]-3,5-Dihydroxy-6-Heptenoic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.