Description

2-Chloro-5,6,7,8-Tetrahydro-[1,6]Naphthyridine-3-Carboxylic Acid Methyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways. It is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for drug discovery and scale-up processes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, especially within the naphthyridine and tetrahydroisoquinoline chemical classes.
• API Synthesis: Used in multi-step synthetic routes for constructing complex molecules with potential therapeutic activity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for the kilogram-scale production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Can be utilized to create tool compounds for investigating biological targets and pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	2-Chloro-5,6,7,8-Tetrahydro-[1,6]Naphthyridine-3-Carboxylic Acid Methyl Ester
CAS No.	767260-86-6
Molecular Formula	C₁₁H₁₁ClN₂O₂
Molecular Weight	238.67 g/mol
Synonyms	Methyl 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylate; 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine-3-carboxylic acid methyl ester; 767260-86-6; 2-Chloro-5,6,7,8-tetrahydro[1,6]naphthyridine-3-carboxylic acid methyl ester; Methyl 2-chloro-5,6,7,8-tetrahydro[1,6]naphthyridine-3-carboxylate; 3-Carbomethoxy-2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine
EINECS	Contact for details

Quality Control

Our 2-Chloro-5,6,7,8-Tetrahydro-[1,6]Naphthyridine-3-Carboxylic Acid Methyl Ester is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Specifications can be tailored to meet the requirements of research, development, or cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.