Description

2-Chloro-5,6,7,8-Tetrahydro-1,6-Naphthyridine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic chemistry. It is essential for research and development chemists and manufacturers in the global pharmaceutical, agrochemical, and fine chemical industries seeking reliable, high-quality intermediates for innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• API Synthesis: Serves as a crucial building block for constructing complex molecular architectures in Active Pharmaceutical Ingredient (API) manufacturing processes.
• Medicinal Chemistry Research: Used in research laboratories for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Agrochemical Development: Employed as an intermediate in the research and production of advanced crop protection agents and pesticides.
• Fine Chemical Synthesis: Utilized in custom synthesis and the production of specialty chemicals requiring a functionalized tetrahydro-naphthyridine core.
• Contract Manufacturing (CDMO): Supplied to Contract Development and Manufacturing Organizations for use in client-specific synthesis projects under cGMP conditions.

Basic Information

Product Name	2-Chloro-5,6,7,8-Tetrahydro-1,6-Naphthyridine Hydrochloride
CAS No.	766545-20-4
Molecular Formula	C8H10ClN2•HCl
Molecular Weight	207.09 g/mol (Free base: 170.63 g/mol)
Synonyms	2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine HCl; 2-Chloro-5,6,7,8-tetrahydro[1,6]naphthyridine hydrochloride; 1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro-, hydrochloride (1:1); 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine monohydrochloride; 766545-20-4; CAS 766545-20-4
EINECS	Contact for details

Quality Control

Our 2-Chloro-5,6,7,8-Tetrahydro-1,6-Naphthyridine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.