Description

(R)-3-Phenyl-3-([4-(4-Pyridin-4-Yl-Phenyl)-Thiophene-2-Carbonyl]-Amino)-Propionic Acid is a high-purity chiral building block and advanced pharmaceutical intermediate designed for complex organic synthesis. Its molecular architecture, featuring a phenylalanine-derived backbone linked to a biaryl-thiophene pharmacophore, makes it a critical component for medicinal chemistry research and development. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing novel therapeutics, particularly in areas requiring specific stereochemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in kinase inhibitor programs.
• Medicinal Chemistry Research: Used as a core scaffold or building block in structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation & Probe Development: The carboxylic acid moiety allows for conjugation to carriers, labels, or other molecules to create biochemical probes.
• Asymmetric Synthesis: Serves as a starting material or intermediate in the synthesis of more complex, stereochemically defined molecules.
• Chemical Biology: Utilized in the development of tool compounds for target validation and pathway analysis in cellular systems.

Basic Information

Product Name	(R)-3-Phenyl-3-([4-(4-Pyridin-4-Yl-Phenyl)-Thiophene-2-Carbonyl]-Amino)-Propionic Acid
CAS No.	766536-21-4
Molecular Formula	C25H20N2O3S
Molecular Weight	428.50 g/mol
Synonyms	(R)-3-Phenyl-3-((4-(4-(pyridin-4-yl)phenyl)thiophene-2-carboxamido)propanoic acid; (R)-3-([4-(4-Pyridin-4-yl-phenyl)-thiophene-2-carbonyl]-amino)-3-phenyl-propionic acid; (R)-3-Phenyl-3-[[4-[4-(4-pyridinyl)phenyl]-2-thienyl]carbonyl]amino]propanoic acid; 766536-21-4; UNII-9W3G2F2K0W; 9W3G2F2K0W; Propanoic acid, 3-[[4-[4-(4-pyridinyl)phenyl]-2-thienyl]carbonyl]amino]-3-phenyl-, (R)-
EINECS	Contact for details

Quality Control

Our production of (R)-3-Phenyl-3-([4-(4-Pyridin-4-Yl-Phenyl)-Thiophene-2-Carbonyl]-Amino)-Propionic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and undergoes rigorous analytical testing, including chiral purity verification. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.