Description

2-Chloro-5-Iodopyridine-3-Carbonitrile is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and iodo substituents on the pyridine ring, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Ligand Synthesis: Serves as a starting material for creating sophisticated ligands used in catalysis and material science.
• Functional Material Development: Employed in the research and production of organic electronic materials, such as OLEDs and semiconductors.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl systems.
• Nucleophilic Substitution: The chlorine atom allows for further functionalization via nucleophilic aromatic substitution, expanding its utility in scaffold diversification.

Basic Information

Product Name	2-Chloro-5-Iodopyridine-3-Carbonitrile
CAS No.	766515-34-8
Molecular Formula	C6H2ClIN2
Molecular Weight	264.45 g/mol
Synonyms	3-Cyano-2-chloro-5-iodopyridine; 5-Iodo-2-chloropyridine-3-carbonitrile; 2-Chloro-5-iodonicotinonitrile; 2-Chloro-5-iodo-3-pyridinecarbonitrile; 2-Chloro-5-iodo-3-cyanopyridine; 766515-34-8; 2-Chloro-5-iodo-pyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Iodopyridine-3-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to reliable supply and traceable documentation supports your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure the container is kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.