Description

N,n-Diisopropyl-6-(Trifluoromethyl)Nicotinamide is a specialized nicotinamide derivative featuring a trifluoromethyl group, a structural motif of significant interest in modern synthetic chemistry. This compound matters as a versatile and high-value chemical intermediate for constructing more complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and crop protection industries, where its unique fluorinated structure can be leveraged to modulate the biological activity, metabolic stability, and physicochemical properties of target compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological efficacy.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers and advanced organic electronic materials.
• Ligand Synthesis: Employed in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination reactions and studying the influence of fluorine atoms on molecular conformation and reactivity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	N,n-Diisopropyl-6-(Trifluoromethyl)Nicotinamide
CAS No.	765298-12-2
Molecular Formula	C13H17F3N2O
Molecular Weight	274.28 g/mol
Synonyms	6-(Trifluoromethyl)-N,N-diisopropylnicotinamide; N,N-Diisopropyl-6-(trifluoromethyl)pyridine-3-carboxamide; 3-Pyridinecarboxamide, N,N-diisopropyl-6-(trifluoromethyl)-; Nicotinamide, N,N-diisopropyl-6-(trifluoromethyl)-; 765298-12-2; 6-Trifluoromethyl-N,N-diisopropylnicotinamide; Diisopropyl-6-trifluoromethylnicotinamide
EINECS	Contact for details

Quality Control

Our N,n-Diisopropyl-6-(Trifluoromethyl)Nicotinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment supports cGMP and ISO standards for advanced chemical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to strong alkali and fluoride sources; store separately from such materials. Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.