Description

4-(Piperazin-1-Ylmethyl)Phenylboronic Acid is a versatile and high-value boronic acid derivative featuring a piperazine moiety, making it a crucial building block in modern synthetic chemistry. Its primary value lies in its dual functionality, serving as both a boronic acid for Suzuki-Miyaura cross-coupling reactions and a piperazine linker for introducing nitrogen-containing pharmacophores. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of drug candidates, especially those targeting central nervous system (CNS) disorders, due to the piperazine scaffold's prevalence.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid coupling partner for constructing biaryl and heterobiaryl structures in medicinal chemistry and material science.
• Ligand Synthesis: Used in the preparation of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Employed in the design and synthesis of new herbicides, fungicides, and plant growth regulators.
• Chemical Biology Probes: Facilitates the creation of molecular probes for studying biological pathways and protein interactions.
• Polymer Modification: Acts as a functional monomer or cross-linker for introducing specific chemical handles into polymeric materials.

Basic Information

Product Name	4-(Piperazin-1-Ylmethyl)Phenylboronic Acid
CAS No.	763120-63-4
Molecular Formula	C11H17BN2O2
Molecular Weight	220.08 g/mol
Synonyms	[4-(Piperazin-1-ylmethyl)phenyl]boronic acid; 4-(Piperazin-1-ylmethyl)benzeneboronic acid; (4-(Piperazin-1-ylmethyl)phenyl)boronic acid; B-[4-(1-Piperazinylmethyl)phenyl]boronic acid; 4-Piperazin-1-ylmethyl-phenylboronic acid; Phenylboronic acid, 4-(1-piperazinylmethyl)-; 763120-63-4; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Every batch of 4-(Piperazin-1-Ylmethyl)Phenylboronic Acid is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure compliance with the highest purity standards suitable for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.