Description

Spiro[2.3]Hexane-1-Carboxylic Acid, 1-Amino-, Methyl Ester is a specialized spirocyclic amino acid ester building block of significant interest in advanced organic synthesis. This compound matters for its unique constrained three-dimensional structure, which is highly valuable for modulating the physicochemical properties and biological activity of target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry: Used to introduce conformational rigidity into peptide mimetics and small molecule libraries to explore structure-activity relationships (SAR).
• Agrochemical Synthesis: Serves as a precursor in the development of new generation herbicides and fungicides with novel modes of action.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Asymmetric Synthesis: Acts as a chiral auxiliary or scaffold in stereoselective synthesis to create enantiomerically pure compounds.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific thermal or mechanical properties.

Basic Information

Product Name	Spiro[2.3]Hexane-1-Carboxylic Acid, 1-Amino-, Methyl Ester
CAS No.	761394-75-6
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	1-Aminosspiro[2.3]hexane-1-carboxylic acid methyl ester; Methyl 1-amino-1-spiro[2.3]hexanecarboxylate; 1-Amino-spiro[2.3]hexane-1-carboxylic acid methyl ester; Spiro[2.3]hexane-1-carboxylic acid, 1-amino-, methyl ester; (1S)-1-Amino-1-spiro[2.3]hexanecarboxylic acid methyl ester; (1R)-1-Amino-1-spiro[2.3]hexanecarboxylic acid methyl ester; Methyl 1-aminospiro[2.3]hexane-1-carboxylate
EINECS	Contact for details

Quality Control

Our Spiro[2.3]Hexane-1-Carboxylic Acid, 1-Amino-, Methyl Ester is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider holding under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (enantiomer specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.