Description

Spiro[2.2]Pentanecarboxylic Acid, 1-Amino-2-Methylene- (9Ci) is a specialized spirocyclic building block featuring a unique, rigid bicyclic structure with both amino and carboxylic acid functional groups. This compound is valued for its ability to introduce significant three-dimensional complexity and specific stereochemical constraints into target molecules, which is critical for modulating biological activity and physical properties. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, asymmetric synthesis, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, particularly in programs targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where its spirocyclic core can enhance metabolic stability and target specificity.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating sophisticated chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Monomer: Potential use in synthesizing specialty polymers with tailored thermal and mechanical properties due to its rigid, multi-functional structure.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes and tools for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	Spiro[2.2]Pentanecarboxylic Acid, 1-Amino-2-Methylene- (9Ci)
CAS No.	760929-97-3
Molecular Formula	C7H9NO2
Molecular Weight	139.15 g/mol
Synonyms	1-Amino-2-methylenespiro[2.2]pentane-1-carboxylic acid; 1-Amino-2-methylenespiropentane-1-carboxylic acid; 2-Methylene-1-aminospiro[2.2]pentane-1-carboxylic acid; 1-Amino-2-methylenespiro[2.2]pentanecarboxylic acid; 1-Aza-3-methylenespiro[2.2]pentane-1-carboxylic acid (tautomeric form); CAS 760929-97-3
EINECS	Contact for details

Quality Control

Our Spiro[2.2]Pentanecarboxylic Acid, 1-Amino-2-Methylene- (9Ci) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports development and cGMP-grade production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. For long-term storage, consider refrigeration at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.