Description

1H-Pyrrolo[2,3-B]Pyridine-3-Carbonitrile, 5-Bromo-1-(Phenylsulfonyl)- is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring a pyrrolopyridine scaffold with bromo, cyano, and phenylsulfonyl substituents, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, receptor antagonists, and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic structure.
• Material Science: Serves as a building block for organic electronic materials, such as ligands for OLEDs or charge-transport materials, due to its electron-deficient π-system.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tool compounds for studying biological pathways and protein function.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse aryl or alkynyl groups.
• Functional Group Transformation: The cyano group can be hydrolyzed to carboxylic acids or reduced to amines, enabling further derivatization and library synthesis.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carbonitrile, 5-Bromo-1-(Phenylsulfonyl)-
CAS No.	757978-34-0
Molecular Formula	C14H8BrN3O2S
Molecular Weight	362.20 g/mol
Synonyms	5-Bromo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile; 5-Bromo-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile; 5-Bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (common alias); 5-Bromo-1-(phenylsulfonyl)-7-azaindole-3-carbonitrile; 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile, 1-(phenylsulfonyl)- derivative; 757978-34-0; 1-(Phenylsulfonyl)-5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-3-Carbonitrile, 5-Bromo-1-(Phenylsulfonyl)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full transparency and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.