Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-3-Iodo-1-(Phenylsulfonyl)- is a high-purity, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it provides a versatile and functionalized core structure for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on kinase inhibitors, targeted cancer therapies, and other small-molecule drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other biologically active heterocyclic compounds.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns for constructing diverse compound libraries via cross-coupling reactions.
• Agrochemical Development: Serves as a building block for creating new active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Potential monomer or precursor for functionalized polymers and organic electronic materials due to its electron-rich pyrrolopyridine core.
• Chemical Biology: Utilized in the development of molecular probes and tool compounds for studying biological pathways and target engagement.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-3-Iodo-1-(Phenylsulfonyl)-
CAS No.	757978-19-1
Molecular Formula	C13H8BrIN2O2S
Molecular Weight	462.09 g/mol
Synonyms	5-Bromo-3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Phenylsulfonyl)-5-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-3-iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common alias); 7-Azaindole, 5-bromo-3-iodo-1-(phenylsulfonyl)-; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-3-iodo-1-(benzenesulfonyl)-; 757978-19-1; 5-Br-3-I-1-Ps-7-azaindole
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-3-Iodo-1-(Phenylsulfonyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.