Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile, 3-Iodo-1-(Phenylsulfonyl)- is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is critical for medicinal chemistry research and pharmaceutical development, serving as a key intermediate in the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries to introduce specific molecular complexity and functionality into target compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and oncology research programs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical space.
• Agrochemical Synthesis: Serves as a precursor in the development of new active ingredients for crop protection.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.
• Material Science Research: Potential precursor for the synthesis of specialized organic electronic materials or ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and development-scale batches.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile, 3-Iodo-1-(Phenylsulfonyl)-
CAS No.	757978-12-4
Molecular Formula	C14H8IN3O2S
Molecular Weight	409.20 g/mol
Synonyms	3-Iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile; 1-(Benzenesulfonyl)-3-iodo-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile; 3-Iodo-1-tosyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile (common alias); 7-Azaindole-5-carbonitrile derivative; Iodinated pyrrolopyridine sulfonamide
EINECS	Contact for details

Quality Control

Every batch of 1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile, 3-Iodo-1-(Phenylsulfonyl)- is produced under strict quality management protocols. We ensure high purity and batch-to-batch consistency through comprehensive analytical testing, including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.