Description

3-Iodo-1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring both an iodine substituent and a nitrile group on a fused pyrrolopyridine core, makes it a versatile intermediate for constructing complex pharmacophores. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel kinase inhibitors, anticancer agents, and other biologically active small molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold.
• Material Science: Acts as a building block for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex substituents.
• Chemical Biology: Utilized as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies and target identification.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploratory synthesis projects.

Basic Information

Product Name	3-Iodo-1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile
CAS No.	757978-11-3
Molecular Formula	C8H4IN3
Molecular Weight	269.04 g/mol
Synonyms	3-Iodo-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile; 5-Cyano-3-iodo-1H-pyrrolo[2,3-b]pyridine; 3-Iodo-5-cyano-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine-5-carbonitrile, 3-iodo-; 757978-11-3; 3-Iodo-1H-7-azaindole-5-carbonitrile
EINECS	Contact for details

Quality Control

Our 3-Iodo-1H-Pyrrolo[2,3-B]Pyridine-5-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.