Description

1H,2H,3H,4H,5H-Pyrido[2,3-B][1,4]Diazepin-2-One is a high-purity, advanced pharmaceutical intermediate belonging to the diazepine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and development programs, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in academic and industrial R&D labs.
• Active Pharmaceutical Ingredient (API) Synthesis: A crucial building block for constructing the core scaffold of potential APIs, especially those with diazepine or fused heterocyclic structures.
• Biochemical Research: Employed as a tool compound or ligand in biochemical assays to study protein-ligand interactions and enzyme inhibition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.
• Reference Standard: Provided as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	1H,2H,3H,4H,5H-Pyrido[2,3-B][1,4]Diazepin-2-One
CAS No.	757966-64-6
Molecular Formula	C9H11N3O
Molecular Weight	177.20 g/mol
Synonyms	Pyrido[2,3-b][1,4]diazepin-2(1H)-one, 1,2,3,4,5-tetrahydro-; 1,2,3,4,5-Tetrahydro-2H-pyrido[2,3-b][1,4]diazepin-2-one; 2H-Pyrido[2,3-b][1,4]diazepin-2-one, 1,3,4,5-tetrahydro-; 757966-64-6; SCHEMBL2180627; BCP31933; AKOS025247324; ZINC000004143756
EINECS	Contact for details

Quality Control

Our 1H,2H,3H,4H,5H-Pyrido[2,3-B][1,4]Diazepin-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We can supply material compliant with research-grade standards and support development toward cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The material should be kept under an inert atmosphere if long-term storage is anticipated to prevent potential degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.