Description

4-(4-Amino-3-Fluorophenoxy)-Pyridine-2-Carboxylic Acid Amide is a high-purity, advanced pharmaceutical intermediate characterized by its unique fluorinated aromatic and pyridine-carboxamide structure. This compound is of significant commercial value for its role in the synthesis of novel, targeted therapeutic agents, particularly in oncology and other disease areas. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of small-molecule drugs and kinase inhibitors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially kinase inhibitors.
• Oncology Drug Research: Used in the R&D of targeted cancer therapies due to its specific molecular scaffold.
• Chemical Biology Probes: Serves as a core structure for developing probes to study enzyme function and signal transduction pathways.
• Agrochemical Research: Potential intermediate for developing new generation herbicides or fungicides with selective activity.
• Material Science: Can be utilized in the synthesis of specialized ligands for catalysts or functional organic materials.

Basic Information

Product Name	4-(4-Amino-3-Fluorophenoxy)-Pyridine-2-Carboxylic Acid Amide
CAS No.	757251-54-0
Molecular Formula	C12H10FN3O2
Molecular Weight	247.23 g/mol
Synonyms	4-(4-Amino-3-fluorophenoxy)picolinamide; 2-Pyridinecarboxamide, 4-[(4-amino-3-fluorophenyl)oxy]-; 4-[(4-Amino-3-fluorophenoxy)]picolinamide; 4-(4-Amino-3-fluorophenoxy)picolinamide; Picolinamide, 4-[(4-amino-3-fluorophenyl)oxy]-; CAS 757251-54-0; 4-(4-Amino-3-fluorophenoxy)-2-pyridinecarboxamide
EINECS	Contact for details

Quality Control

Our production of 4-(4-Amino-3-Fluorophenoxy)-Pyridine-2-Carboxylic Acid Amide adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.