Description

Methyl 1-Cbz-Azetidine-3-Carboxylate is a high-purity, protected azetidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the efficient construction of novel, nitrogen-containing heterocyclic scaffolds. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel azetidine-based drug candidates targeting a range of therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space.
• Peptidomimetic Synthesis: Serves as a constrained, proline-like building block for the design and synthesis of peptide analogs and mimetics.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for studying biological pathways.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Used in university and institutional labs for methodological development in heterocyclic and synthetic organic chemistry.

Basic Information

Product Name	Methyl 1-Cbz-Azetidine-3-Carboxylate
CAS No.	757239-60-4
Molecular Formula	C13H15NO4
Molecular Weight	249.26 g/mol
Synonyms	Methyl 1-[(benzyloxy)carbonyl]azetidine-3-carboxylate; 1-Cbz-3-Carbomethoxyazetidine; 1-(Benzyloxycarbonyl)azetidine-3-carboxylic acid methyl ester; Methyl 1-(benzyloxycarbonyl)azetidine-3-carboxylate; Azetidine-3-carboxylic acid, 1-[(phenylmethoxy)carbonyl]-, methyl ester; Methyl N-Cbz-azetidine-3-carboxylate; 757239-60-4
EINECS	Contact for details

Quality Control

Our Methyl 1-Cbz-Azetidine-3-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of our global pharmaceutical and fine chemical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product should be kept under an inert atmosphere for long-term storage to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.