Description

Cyclopropanecarboxylic Acid, 1-Amino-2,2,3-Trimethyl-, Methyl Ester, cis- (9Ci) is a specialized chiral cyclopropane derivative, a high-value building block in advanced organic synthesis. Its unique sterically hindered cis-configured cyclopropane ring with adjacent amino and ester functionalities makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the cyclopropane moiety can impart specific biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to control stereochemistry in chemical reactions.
• Fine Chemical Production: Employed in the multistep synthesis of complex fragrance and flavor molecules that require precise stereochemical control.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic chemistry, exploring new cyclopropanation and ring-functionalization reactions.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-Amino-2,2,3-Trimethyl-, Methyl Ester, cis- (9Ci)
CAS No.	757156-85-7
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	cis-1-Amino-2,2,3-trimethylcyclopropanecarboxylic acid methyl ester; Methyl cis-1-amino-2,2,3-trimethylcyclopropanecarboxylate; (1R,3S)-1-Amino-2,2,3-trimethylcyclopropanecarboxylic acid methyl ester (if enantiomerically pure); (1S,3R)-1-Amino-2,2,3-trimethylcyclopropanecarboxylic acid methyl ester; 1-Amino-2,2,3-trimethylcyclopropanecarboxylic acid methyl ester, cis-; Aminomethyltrimethylcyclopropanecarboxylate; ATCMPM ester
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for this advanced intermediate. Production adheres to current Good Manufacturing Practice (cGMP) principles where applicable, ensuring batch-to-batch consistency for research and scale-up activities. Identity, purity, and enantiomeric excess (where specified) are verified using advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	Contact for details (racemic or enantiopure grades available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.