Description

3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is of significant commercial value for its role in the synthesis of targeted therapeutic agents, where precise molecular architecture is critical for bioactivity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly within oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for targeted therapies.
• Oncology Drug Research: Used in the R&D of novel anti-cancer compounds, leveraging its specific halogen-substituted phenyl and pyridine motifs.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor in the creation of potent and selective kinase inhibitors.
• Chemical Biology & Proteomics: Employed as a tool compound or a tagged ligand for studying protein-ligand interactions and target engagement.
• Process Chemistry & Scale-Up: Utilized in route scouting, optimization, and pilot-scale production for clinical trial material.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis projects requiring high-fidelity chemical intermediates.

Basic Information

Product Name	3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridin-2-Amine
CAS No.	756520-67-9
Molecular Formula	C13H11Cl2FN2O
Molecular Weight	301.15 g/mol
Synonyms	2-Amino-3-[(1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridine; 3-[(1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-2-pyridinamine; 756520-67-9; 3-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine; 2-Pyridinamine, 3-[(1-(2,6-dichloro-3-fluorophenyl)ethoxy]-; 3-[(1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-2-aminopyridine
EINECS	Contact for details

Quality Control

Our production of 3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)Pyridin-2-Amine adheres to stringent quality protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical R&D. All material is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. We operate under a quality management system aligned with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.