Description

Benzyl(2S)-2Amino-3-(Thiophene-2-Yl)Propanoate is a chiral, non-proteinogenic amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in providing a protected, enantiomerically pure thiophene-containing amino acid scaffold, essential for constructing complex molecules with high stereochemical fidelity. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in peptide mimetics, drug discovery, and the development of novel bioactive compounds targeting neurological and oncological pathways.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Peptidomimetic Research: Used to incorporate a thiophene moiety into peptide backbones, enhancing metabolic stability and modulating receptor binding affinity in drug design.
• Asymmetric Synthesis: Serves as a versatile, enantiomerically pure starting material for constructing complex natural products and heterocyclic compounds.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create labeled or modified amino acids for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Potential intermediate in the development of new generation herbicides and fungicides with novel modes of action.

Basic Information

Product Name	Benzyl(2S)-2Amino-3-(Thiophene-2-Yl)Propanoate
CAS No.	755733-01-8
Molecular Formula	C14H15NO2S
Molecular Weight	261.34 g/mol
Synonyms	(S)-Benzyl 2-amino-3-(thiophen-2-yl)propanoate; L-2-Amino-3-(2-thienyl)propionic Acid Benzyl Ester; (S)-2-(Benzyloxycarbonylamino)-3-(2-thienyl)propionic Acid; Benzyl L-2-Amino-3-(2-thienyl)propionate; 2-Thienyl-L-alanine Benzyl Ester; Fmoc-2-Thienylalanine(benzyl ester); Bzl-2-Thienyl-Ala-OH; 755733-01-8
EINECS	Contact for details

Quality Control

Our Benzyl(2S)-2Amino-3-(Thiophene-2-Yl)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting customer specifications and industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and cGMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.