Description

2,5-Pyridinediamine,3,4,5,6-Tetrahydro-4-Methyl-,(4R,5R)-Rel-(9Ci) is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its value lies in its precise molecular architecture, which is critical for constructing complex active pharmaceutical ingredients (APIs) with specific biological activity. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring enantiomerically pure building blocks.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Used as a ligand precursor or a scaffold in catalytic asymmetric reactions to induce chirality in target molecules.
• Medicinal Chemistry Research: Serves as a core structure for structure-activity relationship (SAR) studies and the discovery of new bioactive compounds.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for API manufacturing under Good Manufacturing Practice (GMP) guidelines.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	2,5-Pyridinediamine,3,4,5,6-Tetrahydro-4-Methyl-,(4R,5R)-Rel-(9Ci)
CAS No.	755729-29-4
Molecular Formula	C6H13N3
Molecular Weight	127.19 g/mol
Synonyms	(4R,5R)-4-Methyl-1,2,3,6-tetrahydropyridine-2,5-diamine; rel-(4R,5R)-4-Methyl-3,4,5,6-tetrahydro-2,5-pyridinediamine; 3,4,5,6-Tetrahydro-4-methyl-2,5-pyridinediamine, (4R,5R)-rel-; (4R,5R)-rel-4-Methyl-3,4,5,6-tetrahydro-2,5-pyridinediamine; 2,5-Diamino-4-methyl-1,2,3,6-tetrahydropyridine, (4R,5R)-rel-; Chiral tetrahydropyridinediamine derivative; Pharmaceutical intermediate 755729-29-4.
EINECS	Contact for details

Quality Control

Our 2,5-Pyridinediamine,3,4,5,6-Tetrahydro-4-Methyl-,(4R,5R)-Rel-(9Ci) is manufactured under strict quality systems to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive analytical data, including HPLC/Chiral HPLC for purity and enantiomeric excess (ee) determination, and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, and custom synthesis to meet specific pharmacopeial or internal specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.