Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 1-[(1,1-Dimethylethyl)Dimethylsilyl]- is a high-purity, protected heterocyclic carboxylic acid derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile and protected synthetic intermediate, enabling the construction of complex molecular architectures with high precision. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and other targeted therapy research.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, leveraging its fused heterocyclic core for biological activity.
• Material Science Research: Serves as a precursor for organic electronic materials, ligands for catalysts, and other functional organic molecules.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploratory chemistry projects.
• Peptidomimetics & Bio-conjugation: The protected carboxylic acid group is ideal for controlled coupling reactions in peptide analog and bioconjugate synthesis.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 1-[(1,1-Dimethylethyl)Dimethylsilyl]-
CAS No.	754214-41-0
Molecular Formula	C14H20N2O2Si
Molecular Weight	276.41 g/mol
Synonyms	1-[(1,1-Dimethylethyl)dimethylsilyl]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 1-(tert-Butyldimethylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 1-TBDMS-7-azaindole-5-carboxylic acid; 1-(tert-Butyldimethylsilyl)-7-azaindole-5-carboxylic acid; 1-TBDMS-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 5-Carboxy-1-TBDMS-7-azaindole; 1-TBDMS-5-carboxy-7-azaindole; 1-(tert-Butyldimethylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 1-[(1,1-Dimethylethyl)Dimethylsilyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP manufacturing standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.