Description

Spiro[Cyclopropane-1,2-[2H]Pyrimido[1,2-A]Pyrimidine] (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic fused heterocyclic structure. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to explore new molecular entities with potential biological activity.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders or infectious diseases.
• Medicinal Chemistry Building Block: Used in scaffold hopping and structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of lead compounds.
• Agrochemical Research: Serves as a core structure for developing new pesticides or herbicides with novel modes of action.
• Chemical Biology Probe: Can be utilized in the synthesis of molecular probes to study biological pathways and protein functions.
• Academic Research: Employed in universities and research institutes for methodological studies in organic synthesis and heterocyclic chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Item	Detail
Product Name	Spiro[Cyclopropane-1,2-[2H]Pyrimido[1,2-A]Pyrimidine] (9Ci)
CAS No.	754213-70-2
Molecular Formula	C9H9N3
Molecular Weight	159.19 g/mol
Synonyms	Spiro(cyclopropane-1,2'-[2H]pyrimido[1,2-a]pyrimidine); 1'H-Spiro[cyclopropane-1,2'-pyrimido[1,2-a]pyrimidine]; 2H-Spiro[cyclopropane-1,2'-pyrimido[1,2-a]pyrimidine]; 754213-70-2; Spiro[cyclopropane-1,2'-[2H]pyrimido[1,2-a]pyrimidine]; Spiro[cyclopropane-1,2-(2H)pyrimido[1,2-a]pyrimidine]
EINECS	Contact for details

Quality Control

Our Spiro[Cyclopropane-1,2-[2H]Pyrimido[1,2-A]Pyrimidine] (9Ci) is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). For long-term storage, consider keeping the material under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.