Description

Pyridine, 3-[(1E)-2-(3R)-3-Pyrrolidinylethenyl]-5-[(Tetrahydro-2H-Pyran-4-Yl)Oxy]- is a complex, high-purity heterocyclic compound featuring a pyridine core with chiral and functionalized substituents. This advanced intermediate is critical for pharmaceutical research and development, particularly in the synthesis of targeted small-molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to build sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for neurological and metabolic disorder targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its unique pyridine-pyrrolidine scaffold.
• Process Chemistry Development: Employed in scaling up synthetic routes for preclinical and clinical trial material production.
• Agrochemical Synthesis: Acts as a precursor for developing advanced crop protection agents with specific biological activity.
• Ligand and Catalyst Development: The nitrogen-rich structure makes it a candidate for developing novel chiral ligands or organocatalysts.
• Fine Chemical Manufacturing: Used in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	Pyridine, 3-[(1E)-2-(3R)-3-Pyrrolidinylethenyl]-5-[(Tetrahydro-2H-Pyran-4-Yl)Oxy]-
CAS No.	753015-42-8
Molecular Formula	C16H22N2O2
Molecular Weight	274.36 g/mol
Synonyms	3-[(1E)-2-[(3R)-3-Pyrrolidinyl]ethenyl]-5-[(tetrahydro-2H-pyran-4-yl)oxy]pyridine; (R)-3-(2-(Pyrrolidin-3-yl)vinyl)-5-(tetrahydro-2H-pyran-4-yloxy)pyridine; 5-(Oxan-4-yloxy)-3-[(E)-2-[(3R)-pyrrolidin-3-yl]ethenyl]pyridine; CAS 753015-42-8; Advanced Pyridine-Pyrrolidine Intermediate; Chiral Pyridine Derivative; THP-Protected Pyridine Alkaloid Intermediate.
EINECS	Contact for details

Quality Control

Our production of Pyridine, 3-[(1E)-2-(3R)-3-Pyrrolidinylethenyl]-5-[(Tetrahydro-2H-Pyran-4-Yl)Oxy]- adheres to strict quality management systems, ensuring batch-to-batch consistency for research and development. Each lot undergoes comprehensive analytical characterization, including chiral purity verification, to meet the exacting standards of pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.