Description

2-Pyrrolidinecarboxamide, 4-Hydroxy-N,n-Dimethyl-, (2S,4S)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its value lies in its unique pyrrolidine scaffold with multiple functional handles, making it a critical intermediate for constructing complex molecular architectures. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and enzyme inhibitor targets.
• Asymmetric Synthesis: Utilized as a precursor or catalyst ligand in stereoselective reactions to create enantiomerically pure compounds.
• Peptidomimetics & Proline Analogs: Serves as a constrained scaffold for designing peptide mimics and modified amino acid derivatives with enhanced metabolic stability.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and combinatorial chemistry libraries to explore new bioactive molecules.
• Chemical Biology Probes: Used in the synthesis of molecular probes for studying biological pathways and protein interactions.
• Agrochemical Research: Potential intermediate in the development of advanced, chiral agrochemicals with specific modes of action.

Basic Information

Product Name	2-Pyrrolidinecarboxamide, 4-Hydroxy-N,n-Dimethyl-, (2S,4S)- (9Ci)
CAS No.	752974-95-1
Molecular Formula	C7H14N2O2
Molecular Weight	158.20 g/mol
Synonyms	(2S,4S)-4-Hydroxy-N,N-dimethylpyrrolidine-2-carboxamide; (4S)-4-Hydroxy-N,N-dimethyl-L-prolinamide; 4-Hydroxy-N,N-dimethyl-L-prolinamide; (2S,4S)-4-Hydroxy-1-methyl-2-pyrrolidinecarboxamide; L-Prolinamide, 4-hydroxy-N,N-dimethyl-; A chiral hydroxyproline derivative
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarboxamide, 4-Hydroxy-N,n-Dimethyl-, (2S,4S)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.